- CRISPR’s ability to alter genome sequences holds immense promise for medicine and other fields
- The industrial revolution was all about using atoms for human advancement, and the internet revolution was about the magic of bytes, but the next one will be about what we do with genes
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Siddhartha Mukherjee, the Putlizer Prize-winning author, has a penchant for taking complex things and putting them beautifully into context. “Three profoundly destabilizing ideas ricochet through the twentieth century,” he writes in The Gene: An Intimate History, “trisecting it into three unequal parts: the atom, the byte, the gene.”
The Industrial revolution was a revolution of the atom, of physical things—steam power, spinning looms, the internal combustion engine. The information technology and internet revolution which followed was of the byte, with 0s and 1s being manipulated to do magic. Arguably, the next revolution is that of the gene, constructed of our DNA, which fashions life itself.
As the coronavirus pandemic engulfs us, we are fighting back largely with the tools that the genetic revolution has given us. It was Danish botanist Wilhelm Johannsen who coined the word ‘gene’, building on the seminal work done on natural evolution and genetic selection by the reclusive Austrian monk Gregor Mendel.
Darwin and Wallace went on to explain how it is the fittest genes and their carriers that survive. Watson, Crick and Rosalind Franklin provided the next big leap by deciphering the double-helix structure of DNA and solving the mystery of how it replicates. Much like bytes are sequences of 0s and 1s, genes are sequences of four proteins represented by the alphabets A, C, T, G. An epochal moment in the genetic revolution was when Fredrick Sanger, winner of two Nobel prizes, sequenced the ACTGs of proteins and then of DNA itself in the late 20th century.
The 21st century gave us another tectonic advance, when Jennifer Doudna and Emmanuelle Charpentier unveiled the rather jauntily named CRISPR/Cas9, what Dr Eric Lander of MIT said, “could very well be the scientific discovery of the century”.
CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats; Cas9 is for CRISPR– associated Endonuclease. Simply put, CRISPR can recognize specific DNA sequences in our genomes, and using the cutting enzyme Cas9, precisely snip off the targeted sequence. Even more wondrous: this cut-off region can be filled with a new DNA sequence to induce the expression of any desired trait, by altering our gene sequence.
For instance, we could use CRISPR to edit and turn off one of the genes responsible for causing sickle-cell anaemia and curing it, or the same for diabetes, leading to an increase in insulin production. The best part is that this technology is very simple to use, and cheap; so much so that there are DIY CRISPR kits available off the internet. The ability to cure several types of cancers, malaria, and HIV, bioengineering new crops and plants is suddenly within grasp.
The biological origin of CRISPR is fascinating, and our old friends, viruses, play their part here too. We know that viruses cannot live on their own, but work by taking over a cell, manipulating its machinery to replicate until it bursts.
Bacteria are among the earliest denizens of our planets, and over millennia have fought an arms race with viruses. Certain bacteria evolved a way to fight back, by deploying DNA-cutting proteins to slice up any viral genes floating around. The bacteria incorporate tiny fragments of virus DNA into their own genomes, so they could spot a similar one quicker in the future.
They employ a neat trick to keep this genetic memory alive, by spacing out each viral DNA fragment with repetitive palindromic sequences in between. These helped memorize genetic code from virus aggressors of the past, and the next time the virus revisited, the bacteria would arm the Cas9 protein with a copy of this sequence, and like a ‘molecular assassin’, the protein would go out and scissor away anything that matched it.
But if we’re altering the basic building blocks of life, there must be a dark side. If we can edit undesirable characteristics, could we not use it to create humans from scratch—‘designer babies’ with perfect health, teeth and desired complexions. Unsurprisingly, a Chinese geneticist has already attempted it, to a round of criticism from the scientific community. The technology is not perfect. Sometimes the wrong sites get cut, there are risks of setting off unintended mutations. But then, every new technology potentially has a dark side.
Mukherjee called the atom-bit-gene trisection unequal. Arguably, the bit revolution was far bigger than the atom one, and it seems the gene revolution will be even bigger, one where we will attempt to change the basis of our own biology. And now we have the perfect tool for it—CRISPR Cas9.
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- Lowering Emissions by Accelerating Forest Finance (LEAF) Coalition, a collective of the United States, United Kingdom and Norway governments, came up with a $1 billion fund.
- LEAF is supported by transnational corporations (TNCs) like Unilever plc, Amazon.com, Inc, Nestle, Airbnb, Inc as well as Emergent, a US-based non-profit.
- The world lost more than 10 million hectares of primary tropical forest cover last year, an area roughly the size of Switzerland.
- Ending tropical and subtropical forest loss by 2030 is a crucial part of meeting global climate, biodiversity and sustainable development goals. Protecting tropical forests offers one of the biggest opportunities for climate action in the coming decade.
- Tropical forests are massive carbon sinks and by investing in their protection, public and private players are likely to stock up on their carbon credits.
- The LEAF coalition initiative is a step towards concretising the aims and objectives of the Reducing Emissions from Deforestation and Forest Degradation (REDD+) mechanism.
- REDD+ was created by the United Nations Framework Convention on Climate Change (UNFCCC). It monetised the value of carbon locked up in the tropical forests of most developing countries, thereby propelling these countries to help mitigate climate change.
- It is a unique initiative as it seeks to help developing countries in battling the double-edged sword of development versus ecological commitment.
- The initiative comes at a crucial time. The tropics have lost close to 12.2 million hectares (mha) of tree cover last year according to global estimates released by Global Forest Watch.
- Of this, a loss of 4.2 mha occurred within humid tropical primary forests alone. It should come as no surprise that most of these lost forests were located in the developing countries of Latin America, Africa and South Asia.
- Brazil has fared dismally on the parameter of ‘annual primary forest loss’ among all countries. It has lost 1.7 mha of primary forests that are rich storehouse of carbon. India’s estimated loss in 2020 stands at 20.8 kilo hectares.
- Between 2002-2020, Brazil’s total area of humid primary forest reduced by 7.7 per cent while India’s reduced by 3.4 per cent.
- Although the loss in India is not as drastic as in Brazil, its position is nevertheless precarious. For India, this loss is equivalent to 951 metric tonnes worth carbon dioxide emissions released in the atmosphere.
- It is important to draw comparisons between Brazil and India as both countries have adopted a rather lackadaisical attitude towards deforestation-induced climate change. The Brazilian government hardly did anything to control the massive fires that gutted the Amazon rainforest in 2019.
- It is mostly around May that forest fires peak in India. However, this year India, witnessed massive forest fires in early March in states like Odisha, Uttarakhand, Madhya Pradesh and Mizoram among others.
- The European Union’s Copernicus Atmospheric Monitoring Service claimed that 0.2 metric tonnes of carbon was emitted in the Uttarakhand forest fires.
- Implementation of the LEAF Coalition plan will help pump in fresh rigour among developing countries like India, that are reluctant to recognise the contributions of their forest dwelling populations in mitigating climate change.
- With the deadline for proposal submission fast approaching, India needs to act swiftly on a revised strategy.
- Although India has pledged to carry out its REDD+ commitments, it is impossible to do so without seeking knowledge from its forest dwelling population.
Context:-
At the recently concluded Leaders’ Summit on Climate in April 2021, Lowering Emissions by Accelerating Forest Finance (LEAF) Coalition, a collective of the United States, United Kingdom and Norway governments, came up with a $1 billion fund plan that shall be offered to countries committed to arrest the decline of their tropical forests by 2030.
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Why LEAF Coalition?
Brazil & India
According to the UN-REDD programme, after the energy sector, deforestation accounts for massive carbon emissions — close to 11 per cent — in the atmosphere. Rapid urbanisation and commercialisation of forest produce are the main causes behind rampant deforestation across tropical forests.
Tribes, Forests and Government
Disregarding climate change as a valid excuse for the fires, Indian government officials were quick to lay the blame for deforestation on activities of forest dwellers and even labelled them “mischievous elements” and “unwanted elements”.
Policy makers around the world have emphasised the role of indigenous tribes and local communities in checking deforestation. These communities depend on forests for their survival as well as livelihood. Hence, they understand the need to protect forests. However, by posing legitimate environmental concerns as obstacles to real development, governments of developing countries swiftly avoid protection of forests and rights of forest dwellers.
For instance, the Government of India has not been forthcoming in recognising the socio-economic, civil, political or even cultural rights of forest dwellers. According to data from the Union Ministry of Tribal Affairs in December, 2020 over 55 per cent of this population has still not been granted either individual or community ownership of their lands.
To make matters worse, the government has undertaken systematic and sustained measures to render the landmark Scheduled Tribes and Other Traditional Forest Dwellers (Recognition of Forest Rights) Act, 2006 ineffective in its implementation. The Act had sought to legitimise claims of forest dwellers on occupied forest land.
Various government decisions have seriously undermined the position of indigenous people within India. These include proposing amendments to the obsolete Indian Forest Act, 1927 that give forest officials the power to take away forest dwellers’ rights and to even use firearms with impunity.
There is also the Supreme Court’s order of February, 2019 directing state governments to evict illegal encroachers of forest land or millions of forest dwellers inhabiting forests since generations as a measure to conserve wildlife. Finally, there is the lack of data on novel coronavirus disease (COVID-19) deaths among the forest dwelling population;
Tardy administration, insufficient supervision, apathetic attitude and a lack of political intent defeat the cause of forest dwelling populations in India, thereby directly affecting efforts at arresting deforestation.
Way Forward
Tuntiak Katan, a global indigenous leader from Ecuador and general coordinator of the Global Alliance of Territorial Communities, aptly indicated the next steps at the Climate Summit:
“The first step is recognition of land rights. The second step is the recognition of the contributions of local communities and indigenous communities, meaning the contributions of indigenous peoples.We also need recognition of traditional knowledge practices in order to fight climate change”
Perhaps India can begin by taking the first step.